{"id":674,"date":"2024-04-12T15:04:51","date_gmt":"2024-04-12T07:04:51","guid":{"rendered":"http:\/\/www.zenith-vn.com\/?p=674"},"modified":"2024-04-22T15:48:57","modified_gmt":"2024-04-22T07:48:57","slug":"metformin-hydrochloride","status":"publish","type":"post","link":"https:\/\/www.zenith-vn.com\/vi\/metformin-hydrochloride\/","title":{"rendered":"\u00a0Metformin Hydrochloride"},"content":{"rendered":"
D\u01b0\u1ee3c \u0111i\u1ec3n<\/strong><\/strong><\/td>EP9.0<\/td><\/tr>
V\u1ebb b\u1ec1 ngo\u00e0i<\/strong><\/strong><\/td>Tinh th\u1ec3 m\u00e0u tr\u1eafng ho\u1eb7c g\u1ea7n nh\u01b0 tr\u1eafng<\/td><\/tr>
S\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a gi\u1ea3i ph\u00e1p<\/strong><\/td>Trong su\u1ed1t (2.2.1) v\u00e0 kh\u00f4ng m\u00e0u (2.2.2 Ph\u01b0\u01a1ng ph\u00e1p II) (2.2.29)<\/td><\/tr>
Nh\u1eadn bi\u1ebft:<\/strong><\/td><\/td><\/tr>
B: Ph\u1ed5 h\u1ed3ng ngo\u1ea1i<\/td>Ph\u00f9 h\u1ee3p v\u1edbi ph\u1ed5 c\u1ee7a metformin hydrochloride CRS (2.2.24)<\/td><\/tr>
E: ph\u1ea3n \u1ee9ng c\u1ee7a clorua<\/td>N\u00f3 cho ph\u1ea3n \u1ee9ng c\u1ee7a clorua. (2.3.1)<\/td><\/tr>
C\u00e1c ch\u1ea5t li\u00ean quan: (2.2.29)<\/strong><\/strong><\/td><\/td><\/tr>
Cyanoguanidine (t\u1ea1p ch\u1ea5t A)<\/strong><\/td>.02%<\/td><\/tr>
B\u1ea5t k\u1ef3 t\u1ea1p ch\u1ea5t n\u00e0o kh\u00e1c<\/strong><\/td>.05%<\/td><\/tr>
adenin<\/td>.05%<\/td><\/tr>
T\u1ed5ng t\u1ea1p ch\u1ea5t<\/td>.210,2%<\/td><\/tr>
t\u1ea1p ch\u1ea5t F<\/td>.05%<\/td><\/tr>
Kim lo\u1ea1i n\u1eb7ng<\/strong><\/td>10ppm (2.4.8)<\/td><\/tr>
T\u1ed5n th\u1ea5t khi s\u1ea5y<\/strong><\/td>.50.5% (2.2.32)<\/td><\/tr>
Tro sunfat<\/strong><\/td>.1% (2.4.14)<\/td><\/tr>
Dung m\u00f4i d\u01b0 (Metanol)<\/strong><\/strong><\/td>3000ppm<\/td><\/tr>
X\u00e9t nghi\u1ec7m tr\u00ean c\u01a1 s\u1edf kh\u00f4<\/strong><\/td>98.5%\u00a0~ 101.0% (2.2.20)<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

C\u1ea5u tr\u00fac ph\u00e2n t\u1eed:<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

C\u00f4ng th\u1ee9c ph\u00e2n t\u1eed:<\/strong>\u00a0C4<\/sub>H12<\/sub>ClN5<\/sub><\/p>\n\n\n\n

Tr\u1ecdng l\u01b0\u1ee3ng ph\u00e2n t\u1eed<\/strong>:<\/strong>\u00a0\u00a0165.62<\/p>\n\n\n\n

S\u1ef1 mi\u00eau t\u1ea3<\/strong>:<\/strong> Metformin hydrochloride l\u00e0 tinh th\u1ec3 m\u00e0u tr\u1eafng ho\u1eb7c b\u1ed9t k\u1ebft tinh, nhi\u1ec7t \u0111\u1ed9 n\u00f3ng ch\u1ea3y 232\u00b0C (218-220\u00b0C), kh\u00f4ng m\u00f9i, v\u1ecb \u0111\u1eafng, d\u1ec5 tan trong n\u01b0\u1edbc, tan trong metanol, \u00edt tan trong ethanol, kh\u00f4ng tan trong ete v\u00e0 cloroform. .<\/p>\n\n\n\n

\u1ee8ng d\u1ee5ng<\/strong><\/strong>:<\/strong><\/p>\n\n\n\n

Metformin hydrochloride l\u00e0 m\u1ed9t thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft biguanide. Ch\u1ee9c n\u0103ng ch\u00ednh c\u1ee7a n\u00f3 l\u00e0 l\u00e0m gi\u1ea3m s\u1ef1 b\u00e0i ti\u1ebft glucagon trong t\u1ebf b\u00e0o A, th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh chuy\u1ec3n \u0111\u1ed5i glucose th\u00e0nh glycogen v\u00e0 c\u00f3 \u0111\u1eb7c t\u00ednh kh\u00f4ng k\u00edch th\u00edch s\u1ef1 ti\u1ebft insulin c\u1ee7a t\u1ebf b\u00e0o \u03b2 tuy\u1ebfn t\u1ee5y.<\/p>\n\n\n\n

C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft nh\u01b0 sau:<\/p>\n\n\n\n

1. T\u0103ng \u0111\u1ed9 nh\u1ea1y c\u1ea3m c\u1ee7a c\u00e1c m\u00f4 xung quanh v\u1edbi insulin v\u00e0 t\u0103ng c\u01b0\u1eddng s\u1eed d\u1ee5ng glucose qua trung gian insulin.<\/p>\n\n\n\n

2. T\u0103ng c\u01b0\u1eddng s\u1eed d\u1ee5ng glucose \u1edf c\u00e1c m\u00f4 kh\u00f4ng ph\u1ee5 thu\u1ed9c insulin, ch\u1eb3ng h\u1ea1n nh\u01b0 n\u00e3o, t\u1ebf b\u00e0o m\u00e1u, t\u1ee7y th\u1eadn, ru\u1ed9t, da, v.v.<\/p>\n\n\n\n

3. \u1ee8c ch\u1ebf qu\u00e1 tr\u00ecnh t\u1ea1o glucose \u1edf gan v\u00e0 gi\u1ea3m s\u1ea3n l\u01b0\u1ee3ng glycogen c\u1ee7a gan.<\/p>\n\n\n\n

4. \u1ee8c ch\u1ebf s\u1ef1 h\u1ea5p thu glucose c\u1ee7a t\u1ebf b\u00e0o th\u00e0nh ru\u1ed9t.<\/p>\n\n\n\n

5. \u1ee8c ch\u1ebf qu\u00e1 tr\u00ecnh sinh t\u1ed5ng h\u1ee3p v\u00e0 d\u1ef1 tr\u1eef cholesterol, l\u00e0m gi\u1ea3m l\u01b0\u1ee3ng ch\u1ea5t b\u00e9o trung t\u00ednh trong m\u00e1u v\u00e0 m\u1ee9c cholesterol to\u00e0n ph\u1ea7n.<\/p>\n\n\n\n

Tr\u00ean l\u00e2m s\u00e0ng, metformin hydrochloride ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng tu\u00fdp 2 kh\u00f4ng h\u00e0i l\u00f2ng v\u1edbi vi\u1ec7c ki\u1ec3m so\u00e1t ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng \u0111\u01a1n gi\u1ea3n, \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh b\u00e9o ph\u00ec v\u00e0 t\u0103ng insulin m\u00e1u. N\u00f3 kh\u00f4ng ch\u1ec9 c\u00f3 t\u00e1c d\u1ee5ng l\u00e0m gi\u1ea3m l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u m\u00e0 c\u00f2n c\u00f3 th\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng l\u00e0m gi\u1ea3m tr\u1ecdng l\u01b0\u1ee3ng c\u01a1 th\u1ec3 v\u00e0 t\u0103ng insulin m\u00e1u. N\u00f3 c\u00f3 th\u1ec3 c\u00f3 hi\u1ec7u qu\u1ea3 \u0111\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 hi\u1ec7u qu\u1ea3 k\u00e9m c\u1ee7a m\u1ed9t s\u1ed1 sulfonylurea, ch\u1eb3ng h\u1ea1n nh\u01b0 s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p v\u1edbi sulfonylurea, thu\u1ed1c \u1ee9c ch\u1ebf glycosidase \u0111\u01b0\u1eddng ru\u1ed9t ho\u1eb7c thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft thiazolidinedione, t\u1ed1t h\u01a1n l\u00e0 s\u1eed d\u1ee5ng ri\u00eang l\u1ebb. N\u00f3 c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho nh\u1eefng b\u1ec7nh nh\u00e2n \u0111ang \u0111i\u1ec1u tr\u1ecb b\u1eb1ng insulin \u0111\u1ec3 gi\u1ea3m l\u01b0\u1ee3ng insulin.<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u0111\u00f3ng g\u00f3i<\/strong> <\/strong><\/strong><\/strong>:25kg\/th\u00f9ng<\/p>\n\n\n\n

Kho:<\/strong>B\u1ea3o qu\u1ea3n k\u00edn, kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t.<\/p>\n\n\n\n

H\u1ea1n s\u1eed d\u1ee5ng :<\/strong>36 th\u00e1ng k\u1ec3 t\u1eeb ng\u00e0y s\u1ea3n xu\u1ea5t khi \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n trong \u0111i\u1ec1u ki\u1ec7n t\u1ed1t.<\/p>\n\n\n\n

\u0110\u01a1n h\u00e0ng t\u1ed1i thi\u1ec3u<\/strong><\/strong><\/strong>:<\/strong>500kg<\/p>","protected":false},"excerpt":{"rendered":"

Pharmacopoeia EP9.0 Appearance White or almost white crystals Appearance of solution Clear (2.2.1) and colorless (2.2.2 Method II) (2.2.29) Identification: B: IR-spectrum Consistent with the spectrum of metformin hydrochloride CRS (2.2.24) E: reaction of chlorides It gives reaction of chlorides. (2.3.1) Related substances: (2.2.29) Cyanoguanidine (impurity A) \u22640.02% Any other impurity \u22640.05% Adenine \u22640.05% Total […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-674","post","type-post","status-publish","format-standard","hentry","category-pharmaceutical-ingredients"],"_links":{"self":[{"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/posts\/674","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/comments?post=674"}],"version-history":[{"count":1,"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/posts\/674\/revisions"}],"predecessor-version":[{"id":677,"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/posts\/674\/revisions\/677"}],"wp:attachment":[{"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/media?parent=674"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/categories?post=674"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/tags?post=674"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}