{"id":1012,"date":"2025-08-11T14:33:58","date_gmt":"2025-08-11T06:33:58","guid":{"rendered":"https:\/\/www.zenith-vn.com\/?p=1012"},"modified":"2025-08-11T14:35:39","modified_gmt":"2025-08-11T06:35:39","slug":"the-green-vitamin-revolution-three-technological-leaps-in-vitamin-manufacturing","status":"publish","type":"post","link":"https:\/\/www.zenith-vn.com\/vi\/cuoc-cach-mang-vitamin-xanh-ba-buoc-nhay-vot-ve-cong-nghe-trong-san-xuat-vitamin\/","title":{"rendered":"Cu\u1ed9c c\u00e1ch m\u1ea1ng Vitamin xanh \u2013 Ba b\u01b0\u1edbc ti\u1ebfn c\u00f4ng ngh\u1ec7 trong s\u1ea3n xu\u1ea5t Vitamin"},"content":{"rendered":"

Vitamin l\u00e0 m\u1ed9t trong nh\u1eefng vi ch\u1ea5t dinh d\u01b0\u1ee1ng thi\u1ebft y\u1ebfu m\u00e0 c\u01a1 th\u1ec3 con ng\u01b0\u1eddi kh\u00f4ng th\u1ec3 t\u1ef1 t\u1ed5ng h\u1ee3p. L\u00e0 m\u1ed9t nh\u00e0 s\u1ea3n xu\u1ea5t to\u00e0n c\u1ea7u l\u1edbn, ng\u00e0nh s\u1ea3n xu\u1ea5t vitamin c\u1ee7a Trung Qu\u1ed1c \u0111\u00e3 tr\u1ea3i qua ba cu\u1ed9c chuy\u1ec3n \u0111\u1ed5i c\u00f4ng ngh\u1ec7 quan tr\u1ecdng. Giai \u0111o\u1ea1n \u0111\u1ea7u d\u1ef1a v\u00e0o t\u1ed5ng h\u1ee3p h\u00f3a h\u1ecdc, s\u1eed d\u1ee5ng d\u1ea7u m\u1ecf v\u00e0 c\u00e1c s\u1ea3n ph\u1ea9m n\u00f4ng nghi\u1ec7p l\u00e0m nguy\u00ean li\u1ec7u th\u00f4. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y ph\u1ee9c t\u1ea1p v\u00e0 g\u00e2y \u00f4 nhi\u1ec5m cao. Giai \u0111o\u1ea1n th\u1ee9 hai, k\u1ebft h\u1ee3p t\u1ed5ng h\u1ee3p h\u00f3a h\u1ecdc v\u1edbi x\u00fac t\u00e1c enzym, \u0111\u01b0a v\u00e0o ph\u1ea3n \u1ee9ng do enzym th\u00fac \u0111\u1ea9y, gi\u00fap c\u1ea3i thi\u1ec7n \u0111\u1ed9 tinh khi\u1ebft v\u00e0 hi\u1ec7u qu\u1ea3. Th\u1ebf h\u1ec7 th\u1ee9 ba l\u00e0 c\u00f4ng ngh\u1ec7 l\u00ean men sinh h\u1ecdc ho\u00e0n to\u00e0n, \u0111\u00e3 n\u1ed5i l\u00ean nh\u01b0 m\u1ed9t b\u01b0\u1edbc ngo\u1eb7t. B\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng c\u00e1c vi sinh v\u1eadt bi\u1ebfn \u0111\u1ed5i gen, c\u00e1c ngu\u1ed3n t\u00e0i nguy\u00ean t\u00e1i t\u1ea1o nh\u01b0 \u0111\u01b0\u1eddng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c chuy\u1ec3n \u0111\u1ed5i tr\u1ef1c ti\u1ebfp th\u00e0nh vitamin m\u1ee5c ti\u00eau, gi\u00fap gi\u1ea3m \u0111\u00e1ng k\u1ec3 c\u1ea3 m\u1ee9c ti\u00eau th\u1ee5 n\u0103ng l\u01b0\u1ee3ng v\u00e0 \u00f4 nhi\u1ec5m m\u00f4i tr\u01b0\u1eddng.<\/p>\n\n\n\n

C\u00e1c ch\u1ea5t dinh d\u01b0\u1ee1ng ch\u1ee9c n\u0103ng nh\u01b0 vitamin B5 hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t th\u00f4ng qua c\u00e1c c\u00f4ng ngh\u1ec7 ti\u00ean ti\u1ebfn nh\u01b0 k\u1ef9 thu\u1eadt chuy\u1ec3n h\u00f3a, t\u1ed1i \u01b0u h\u00f3a qu\u00e1 tr\u00ecnh l\u00ean men v\u00e0 sinh h\u1ecdc t\u1ed5ng h\u1ee3p, cho ph\u00e9p s\u1ea3n xu\u1ea5t hi\u1ec7u qu\u1ea3 cao, \u00edt carbon v\u00e0 b\u1ec1n v\u1eefng. V\u00ed d\u1ee5, trong qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t VB5, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 h\u1ea1n ch\u1ebf m\u1ea1ng l\u01b0\u1edbi chuy\u1ec3n h\u00f3a c\u1ee7a vi khu\u1ea9n Escherichia coli \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c hi\u1ec7u qu\u1ea3, mang l\u1ea1i m\u1ed9t gi\u1ea3i ph\u00e1p thay th\u1ebf kh\u1ea3 thi cho c\u00e1c ph\u01b0\u01a1ng ph\u00e1p truy\u1ec1n th\u1ed1ng.<\/p>\n\n\n\n

Qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t th\u00f4ng qua qu\u00e1 tr\u00ecnh l\u00ean men sinh h\u1ecdc ho\u00e0n to\u00e0n bao g\u1ed3m qu\u00e1 tr\u00ecnh \u0111i\u1ec1u h\u00f2a chuy\u1ec3n h\u00f3a \u0111a m\u00f4-\u0111un ph\u1ee9c t\u1ea1p, bao g\u1ed3m t\u1ed1i \u01b0u h\u00f3a qu\u00e1 tr\u00ecnh h\u1ea5p th\u1ee5 glucose, chuy\u1ec3n h\u01b0\u1edbng d\u00f2ng carbon trung t\u00e2m v\u00e0 c\u00e2n b\u1eb1ng cofactor. B\u1eb1ng c\u00e1ch \u0111i\u1ec1u ch\u1ec9nh ch\u00ednh x\u00e1c c\u00e1c con \u0111\u01b0\u1eddng s\u1eed d\u1ee5ng glucose v\u00e0 t\u0103ng c\u01b0\u1eddng cung c\u1ea5p pyruvate, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3 n\u0103ng su\u1ea5t v\u00e0 hi\u1ec7u su\u1ea5t chuy\u1ec3n \u0111\u1ed5i VB5. H\u01a1n n\u1eefa, vi\u1ec7c ki\u1ec3m so\u00e1t ch\u1eb7t ch\u1ebd c\u00e1c con \u0111\u01b0\u1eddng c\u1ea1nh tranh v\u00e0 s\u1ef1 h\u00ecnh th\u00e0nh s\u1ea3n ph\u1ea9m ph\u1ee5 l\u00e0 r\u1ea5t c\u1ea7n thi\u1ebft. C\u00e1c c\u00f4ng c\u1ee5 ch\u1ec9nh s\u1eeda gen ti\u00ean ti\u1ebfn nh\u01b0 CRISPR \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 x\u00f3a ho\u1eb7c \u1ee9c ch\u1ebf c\u00e1c con \u0111\u01b0\u1eddng s\u1ea3n sinh axit amin v\u00e0 axit h\u1eefu c\u01a1 kh\u00f4ng mong mu\u1ed1n, gi\u00fap gi\u1ea3m thi\u1ec3u l\u00e3ng ph\u00ed t\u00e0i nguy\u00ean v\u00e0 t\u0103ng c\u01b0\u1eddng t\u00edch l\u0169y s\u1ea3n ph\u1ea9m m\u1ee5c ti\u00eau. Vi\u1ec7c bi\u1ec3u hi\u1ec7n protein ngo\u1ea1i sinh c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c t\u1ed1i \u01b0u h\u00f3a \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng v\u1eadn chuy\u1ec3n n\u1ed9i b\u00e0o v\u00e0 ngo\u1ea1i b\u00e0o c\u1ee7a VB5 v\u00e0 c\u00e1c ti\u1ec1n ch\u1ea5t c\u1ee7a n\u00f3, d\u1eabn \u0111\u1ebfn m\u1ed9t h\u1ec7 th\u1ed1ng s\u1ea3n xu\u1ea5t hi\u1ec7u qu\u1ea3 h\u01a1n.<\/p>\n\n\n\n

Ng\u00e0nh c\u00f4ng nghi\u1ec7p vitamin c\u1ee7a Trung Qu\u1ed1c \u0111ang b\u01b0\u1edbc v\u00e0o k\u1ef7 nguy\u00ean m\u1edbi c\u1ee7a \u0111\u1ed5i m\u1edbi \u0111\u1ed9c l\u1eadp v\u00e0 s\u1ea3n xu\u1ea5t ti\u00ean ti\u1ebfn. Nghi\u00ean c\u1ee9u trong t\u01b0\u01a1ng lai s\u1ebd t\u1eadp trung v\u00e0o vi\u1ec7c gi\u00e1m s\u00e1t th\u00f4ng minh c\u00e1c qu\u00e1 tr\u00ecnh l\u00ean men, \u0111i\u1ec1u ch\u1ec9nh \u0111\u1ed9ng l\u1ef1c h\u1ecdc d\u1ef1a tr\u00ean d\u1eef li\u1ec7u \u0111a \u00f4-m\u00edc v\u00e0 t\u1ed1i \u01b0u h\u00f3a h\u1ec7 th\u1ed1ng c\u00e1c b\u01b0\u1edbc gi\u1edbi h\u1ea1n t\u1ed1c \u0111\u1ed9 quan tr\u1ecdng. M\u1ee5c ti\u00eau l\u00e0 \u0111\u1ea1t \u0111\u01b0\u1ee3c s\u1ef1 t\u0103ng tr\u01b0\u1edfng v\u00e0 s\u1ea3n xu\u1ea5t t\u00e1ch bi\u1ec7t nh\u01b0ng \u0111\u1ed3ng b\u1ed9 trong c\u00e1c ch\u1ee7ng c\u00f4ng nghi\u1ec7p, li\u00ean t\u1ee5c m\u1edf r\u1ed9ng ranh gi\u1edbi v\u1ec1 s\u1ea3n l\u01b0\u1ee3ng v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng.<\/p>\n\n\n\n

Khi c\u00f4ng ngh\u1ec7 sinh h\u1ecdc t\u1ed5ng h\u1ee3p v\u00e0 ph\u00e2n t\u00edch t\u1ef1 \u0111\u1ed9ng h\u1ed9i t\u1ee5, m\u1ed9t th\u1ebf h\u1ec7 nh\u00e0 m\u00e1y vitamin th\u00f4ng minh, \u00edt carbon v\u00e0 xanh m\u1edbi \u0111ang d\u1ea7n tr\u1edf th\u00e0nh hi\u1ec7n th\u1ef1c. S\u1ef1 chuy\u1ec3n \u0111\u1ed5i n\u00e0y kh\u00f4ng ch\u1ec9 h\u1ed7 tr\u1ee3 Trung Qu\u1ed1c chuy\u1ec3n m\u00ecnh t\u1eeb "c\u00f4ng x\u01b0\u1edfng th\u1ebf gi\u1edbi" th\u00e0nh "nh\u00e0 l\u00e3nh \u0111\u1ea1o c\u00f4ng ngh\u1ec7 to\u00e0n c\u1ea7u", m\u00e0 c\u00f2n \u0111\u00f3ng g\u00f3p s\u1ef1 \u0111\u1ed5i m\u1edbi v\u00e0 chuy\u00ean m\u00f4n c\u1ee7a Trung Qu\u1ed1c v\u00e0o c\u00e1c s\u00e1ng ki\u1ebfn dinh d\u01b0\u1ee1ng v\u00e0 s\u1ee9c kh\u1ecfe to\u00e0n c\u1ea7u.<\/p>\n\n\n\n

\"\"<\/figure>","protected":false},"excerpt":{"rendered":"

Vitamin l\u00e0 m\u1ed9t trong nh\u1eefng vi ch\u1ea5t dinh d\u01b0\u1ee1ng thi\u1ebft y\u1ebfu m\u00e0 c\u01a1 th\u1ec3 con ng\u01b0\u1eddi kh\u00f4ng th\u1ec3 t\u1ef1 t\u1ed5ng h\u1ee3p. L\u00e0 m\u1ed9t nh\u00e0 s\u1ea3n xu\u1ea5t vitamin l\u1edbn tr\u00ean th\u1ebf gi\u1edbi, ng\u00e0nh c\u00f4ng nghi\u1ec7p s\u1ea3n xu\u1ea5t vitamin c\u1ee7a Trung Qu\u1ed1c \u0111\u00e3 tr\u1ea3i qua ba cu\u1ed9c chuy\u1ec3n \u0111\u1ed5i c\u00f4ng ngh\u1ec7 \u0111\u00e1ng k\u1ec3. Giai \u0111o\u1ea1n \u0111\u1ea7u d\u1ef1a tr\u00ean t\u1ed5ng h\u1ee3p h\u00f3a h\u1ecdc, s\u1eed d\u1ee5ng d\u1ea7u m\u1ecf v\u00e0 c\u00e1c s\u1ea3n ph\u1ea9m n\u00f4ng nghi\u1ec7p l\u00e0m nguy\u00ean li\u1ec7u th\u00f4. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y ph\u1ee9c t\u1ea1p v\u00e0 g\u00e2y \u00f4 nhi\u1ec5m cao. Giai \u0111o\u1ea1n th\u1ee9 hai, k\u1ebft h\u1ee3p [\u2026]<\/p>","protected":false},"author":2,"featured_media":957,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,4],"tags":[],"class_list":["post-1012","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-company-news","category-news"],"_links":{"self":[{"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/posts\/1012","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/comments?post=1012"}],"version-history":[{"count":1,"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/posts\/1012\/revisions"}],"predecessor-version":[{"id":1013,"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/posts\/1012\/revisions\/1013"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/media\/957"}],"wp:attachment":[{"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/media?parent=1012"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/categories?post=1012"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.zenith-vn.com\/vi\/wp-json\/wp\/v2\/tags?post=1012"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}